This course marks the 15th year of Professor Hideyuki Akaza’s "Cross-boundary Studies." As Japan reaches 80 years since the end of World War II, it continues to advance as a leading nation in addressing the challenges of an aging society. Amidst urbanization, regional disparities, and growing diversity, the country must engage with Asia to achieve well-being on a broader scale. A multifaceted approach is essential, integrating next-generation probiotics research and innovative health models into social implementation. This course will analyze the current state of healthcare and well-being, support the implementation of health education in communities, schools, and workplaces, and promote interdisciplinary education programs for future leaders. Over the past three years, collaboration with Malaysia’s National Cancer Society (NCSM) has facilitated interdisciplinary cancer research. Building on these insights, a side event will be hosted at the ASEAN Summit in Malaysia this September to share Japan’s expertise and contribute to the establishment of a sustainable healthcare system. The knowledge cultivated in this course aims to serve as a foundation for international dialogue and collaboration across Asia.