適応進化遺伝学 - 新領域創成科学研究科

適応進化遺伝学

Evolutionary Genetics *この講義は留学生用に英語で行う。日本語で講義を受ける学生は次年度の47140-21Jを履修すること。 *This is for foreign students.

The purpose of this lecture is to provide theoretical framework for studying adaptive evolution of gene function. Since it is the population and genes that change over evolutionary time, it is essential to acquire basic knowledge of population genetics to understand molecular evolution. I shall review several basic concepts of population genetics such as gene frequencies, natural selection and random genetic drift, then introduce the neutral theory of molecular evolution. On the basis of the theorem, methods and their limitations for detecting adaptive evolution are discussed. Finally, direction of evolutionary genetic study will be discussed.

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授業計画

1. Introduction: history of life, continental drift, extinction, chance events 2. Population genetics I: genetic variation, gene frequency, natural selection 3. Population genetics II: random genetic drift, population differentiation, coalescence, drift-mutation equilibrium 4. Population genetics III: DNA sequence data, nucleotide diversity, coalescence simulation and maximum likelihood estimation, Tajima's D test, linkage disequilibrium 5. Molecular evolution I: nucleotide substitution, evolutionary rate 6. Molecular evolution II: evolutionary distance, phylogenetic tree 7. Neutral theory of molecular evolution: standard null model of genetic variation and evolution 8. Adaptive evolution: within-species polymorphism, between-species divergence, within vs between species variation, nonsynonymous vs synonymous nucleotide substitutions, convergent evolution, methodological limitations, adaptive evolution vs functional evolution 9. Perspectives: testing inference of functional evolution, evolution of gene-interacting system

授業の方法

Lecture using slide-projection along a textbook

成績評価方法

Attendance and submission of examinations

履修上の注意

Examination every after two time units

その他

＜授業情報＞ Intensive course Lecture Room, Bioscience BLDG and Online (hybrid) Tentative dates Dec 8th Tue 1st and 2nd periods 8:30～12:10 Dec 9th Wed 1st and 2nd periods 8:30～12:10 Dec 15th Tue 1st and 2nd periods 8:30～12:10 Dec 16th Wed 1st and 2nd periods 8:30～12:10 Dec 22nd Tue 1st and 2nd periods 8:30～12:10 Dec 23rd Wed 1st and 2nd periods 8:30～12:10