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最終更新日:2024年4月22日

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Overview of Chemical Bioengineering

The behaviors of biosystems are well-regulated and controlled by interactions between various functional biomolecules such as DNA, RNA and proteins in different hierarchies: cells, tissues and organs. On the firm basis on chemistry, the research in the chemical bioengineering field is focused on the structure and functions of these biomolecules, and on the mechanisms for regulating and controlling the biosystems through such molecules. The research is also focused on the innovative technology development for design, synthesis and control of high performance cells, tissues and organs through artificial designing, alteration, modification and systematization of functional biomolecules. Finally, we aim at applying these technologies to the medical treatment field.
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教員
学期
時限
3791-119
GEN-BI5f19L3
Overview of Chemical Bioengineering
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S2
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英語
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1
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NO
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授業計画
1. Activity of cells 1-1 Signal transduction and their regulations in cells 1-2 Communication of cells 1-3 Cellular growth and reaction kinetics 1-4 Metabolism and energetics 2. Biomolecular engineering and application to biotechnology 2-1 Recombinant DNA technology 2-1-1 Gene manipulation methods 2-1-2 Gene transfer methods to cells 2-1-3 Selection methods of transformed cells 2-1-4 Tools to study DNA function 2-2 Protein engineering 2-2-1 Definition and purpose of protein engineering 2-2-2 Translation of mRNA into proteins 2-2-3 Strategy and methods for protein engineering 2-3 Application of biomolecular engineering to Biotechnology 3. Reproduction, embryology and aging 3-1 Reproductive system 3-2 Development of humans and animals 3-3 Fertilization and embryo development 3-4 Development of a fetus and the role of the placenta 3-5 Historical alteration of age and cause of death 3-6 Current status of age and cause of death 3-7 Factors determining human age 3-8 Sustainable aging society and contribution of engineering 4. Regenerative medicine and tissue engineering 4-1 Basics of tissue engineering / regenerative medicine 4-2 Regenerative medicine and tissue engineering in hard tissues 4-2-1 Basics of hard tissue engineering 4-2-2 Tissue engineering of skeletal tissues (bone and cartilage) 4-2-3 Tissue engineering of teeth and periodontal tissues 4-3 Regenerative medicine and tissue engineering in soft tissues 4-3-1 Basics of soft tissue engineering 4-3-2 Design and organization of soft tissue 4-3-3 Liver tissue engineering 4-3-4 Pancreas beta cell tissue engineering 4-3-5 Engineering of other large metabolic tissues 5. Drug development and efficacy/toxicity evaluation 5-1 Drug development process and its future 5-2 Molecular level screening in drug development 5-3 Important toxicities in drug development 5-4 Animal-free evaluation of efficacy/toxicity 5-5 Integration of animal-free evaluation to the whole body level 5-6 Integration of various technologies toward mechanism-based efficacy/toxicity evaluation 6. Hematology and Endocrinology 6-1 Oxygen and evolution 6-2 Respiratory system and lung 6-3 Microcirculation 6-4 Erythrocyte 6-5 Platelets and blood plasma 6-6 Basic endocrinology 7. Immunology 7-1 Phagocytes and innate immune system 7-2 Lymphocytes and adaptive immune system 7-3 Immune response to biomaterials
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