化学特別講義III

Day 1: Foundations and Recognition Chemistry Lecture 1: Physical and Chemical Foundations of Nucleic Acids (Structure, biostability, chemical modifications and sequencing chemistry) Lecture 2: Molecular Recognition and Aptamer Engineering (Principles of Cell-SELEX and "Chemical Antibodies") Lecture 3: Nucleic Acid Barcoding and Information Encoding (Translating biological signals and information into digital DNA sequences) Day 2: Advanced Analysis and Spatiotemporal Omics Lecture 4: Single-Cell Sequencing and Microfluidic Chemistry (High-throughput transcriptomics and droplet-based systems) Lecture 5: Liquid Biopsy and Rare Biomarker Analysis (Microfluidic enrichment of CTCs and exosomes) Lecture 6 (Seminar): Spatially Resolved Chemical Barcoding: Decoding the Spatiotemporal Dynamics of Life (Advanced tissue decoding via Decoder-seq) — Suitable for both students and faculty.

I will provide comprehensive lecture slides and a curated list of key research papers (including our recent works in Nature Biotechnology, JACS, and Angewandte Chemie) for the students. The sessions will be interactive, focusing on the chemical logic behind technology development. No specific textbook is required.

The attendance/Reports or test

Basic knowledge of biomolecules is required.