有機化学特論Ⅲ

上杉教授がネット配信し、全世界で8万人が受講した「The Chemistry of Life」のリアル授業。この授業では、研究室、就活、企業で将来活躍するための演習をおこなう。つまり、知識を得るだけではなく、得た知識を道具にしてアイデアを出す力（生産力）を養う。結果だけを積み重ねた知識は、すぐに色あせる。これからの時代に必要なのは、どのように知識を使ってアイデアを出し、どう他人を説得するかだ。
　生き物の営みは化学（つまり分子の働き）でなりたっている。生き物の仕組みの全てを化学で語ることができるはず。そして、化学は「物質を作り出す学問」でもある。生き物を本当に化学で理解したのならば、生き物の仕組みを化学で人工的に作ったり、化学の力で生き物の営みを操る物質を創造することができる。生命の有機化学は、化学と生物の両方の知識を道具にしてアイデアの出し方を学ぶには好都合な分野なのだ。化学と生物学の基本的事項を身につけながら、自分でいろいろなアイデアを生んで生産的な人材になることを目標とする。
　この目的を達成するために、インターネットを活用した反転授業（Flipped Classroom）を行う。インターネット上の短い講義ビデオを自宅で視聴し、実際の教室ではインターラクティブなアクティビティ（演習と議論）を行い、議論の内容に応じて高度な実際の研究内容を講義する。ビデオ視聴以外の宿題は課さない。ビデオは京都大学Open Coursewareで常時公開されている。https://ocw.kyoto-u.ac.jp/*****

This course is the in-person version of “The Chemistry of Life,” a course delivered online by Professor Uesugi that has attracted more than 80,000 learners worldwide. In this class, students engage in exercises designed to help them be successful in a research career and job hunting. The goal is not merely to acquire knowledge, but to cultivate the ability to generate ideas using knowledge as a tool. Knowledge that consists only of accumulated results quickly becomes outdated. In the future, what is essential is the ability to use knowledge creatively to generate new ideas and to communicate and persuade others effectively.

All biological events are governed by chemistry. In principle, every mechanism of life should be describable in chemistry. Chemistry is also the discipline that creates unnatural molecules and materials. If we truly understand biological systems through chemistry, we should be able to reconstruct biological mechanisms using chemical approaches or design molecules that control biological processes.

The field of organic chemistry of life, therefore, provides an ideal framework for learning how to generate ideas by integrating knowledge from both chemistry and biology. Through this course, students will acquire fundamental concepts in chemical biology while developing the ability to create their own ideas.

To achieve these goals, the course adopts a flipped classroom model utilizing online resources. Students watch short lecture videos online before class, and class time is devoted to interactive activities, including exercises and discussions. Depending on the direction of the discussions, the instructor will introduce advanced topics from real research. No homework is assigned other than watching the lecture videos. All videos are available through Kyoto University OpenCourseWare: https://ocw.kyoto-u.ac.jp/*****

Students should watch the following units before class:
Unit 5: Writing Amino Acids (38 min)
If you are already familiar with the single-letter codes of amino acids, you may skip this unit.
Unit 6: Writing and Synthesizing Proteins (57 min)
If you are familiar with the characteristics of peptide bonds, you may skip Parts 1–5 and focus on Parts 6–9. This is a main video for the course.
Unit 7: Combinatorial Chemistry and Chemical Genetics (34 min)
Main video for the course.
Unit 8: Fluorescent Molecules for Tracking Biology (38 min)
Main video for the course.
Unit 9: Fluorescent Proteins for Tracking Biology (41 min)
Main video for the course.