Nanoscience

Part I: Biotechnology Classroom: S1 Seminar Room, West building, Faculty of Pharmaceutical Sciences This sub-course focuses on advanced biomedical science and technology bound to the drug discovery. (1) Title: Therapeutic antibodies and biologic agents July 16 (Mon) 8:30-10:15 (Prof. Masashi HONMA) Outline： - Soluble form receptors or ligands - Monoclonal antibodies - Other biologic agents - Manufacturing systems - Clinical problems (2) Title: Lipidomics: Technologies and Applications in Medical Research July 16 (Mon) 10:25-12:10 (Prof. Nozomu KONO) Outline： -Lipids and lipidomics. -Technologies for lipidomics. -Applications of lipidomics in Medical Research. (3) Lab Tour: July 16 (Mon) 12:20-13:20 (4) Title: Impact of single-molecule biophysics on life sciences July 17 (Tue) 8:30-10:15 (Prof. Takashi FUNATSU) Outline: Creatures are composed of various and many biomolecules. Among them, protein molecules play a major role in life function. Techniques of imaging and manipulating single biomolecules enabled us to study enzymatic reactions, motor protein movement, and protein-protein interactions at single-molecular level. The techniques are also applied to single-molecule DNA sequencer and super-resolution microscopy. This lecture introduces the principles and applications of single-molecule fluorescence microscopy. (5) Title: (2) Total synthesis and biological evaluation of structurally complex natural products July 17 (Tue) 10:25-12:10 (Prof. Masayuki INOUE) Outline: Natural products have been tremendously important in biology and human medicine because they modulate signal transductions of biological system. Three-dimensional structures of natural products are highly optimized for function through evolutionary processes. Chemical construction of their entire structures is necessary to provide sufficient amounts of material required for biological and medical applications. In our research, we develop new and efficient synthetic methodologies and strategies for the synthesis of highly complex compounds. We then apply the synthetic natural products and designed artificial analogs for studying new functions and network of biological systems. (6) Lab Tour: July 17 (Tue) 12:10-13:40 Part II: Biomedicine and Nanobiotechnology Place: Faculty of Engineering Building No. 12 (Asano Campus), 2nd Floor, Meeting Room No. 219-221 This sub-course focuses on the understanding of the structure and functions of the living systems at the nano level as a basis for the development of bioinspired structures and functions as well as for the establishment of methodologies to integrate living components, including biomolecules and cells, into nanodevices while regulating their functions. To effectively achieve this goal, the course sets 4 topics: (1) Biodevice Technology (2) Mechano-bioengineering (4) Nano Bioelectronics and Biophotonics, (5) Nanotechnology and Materials Science for Nanoscale Cell Therapy and Lab tour (3) & (6). (1) Biodevice Technology July 11 (Thu) 8:30-10:15 (Prof. Takanori ICHIKI) “Biodevice Technologies for Cancer Diagnosis” To overcome cancer and other intractable diseases, we need to create a seamless, comprehensive process where the heralding signs and lesions of diseases are precisely detected by early diagnosis via screening and by accurate diagnosis using imaging techniques, highly effective and safe treatment is provided by combining surgeries as topical treatments and drug therapies as systemic treatments based on the condition of the disease, and the lesion is reconstructed after treatment. In this lecture, I will review development of cancer diagnosis systems using new biomarkers such as micro RNA and exosomes, and show a prospect that the time required for cancer diagnosis can be greatly shortened to less than one hour by the recent progress in nanobiodevice technology. (2) Mechano-bioengineering July 11 (Thu) 10:25-12:10 (Prof. Ichiro SAKUMA) Outline: “Computer Aided Surgery and Surgical Robotics” Minimally invasive therapy such as endoscopic surgery and catheter based intervention since less pain and complication due to intervention. However, surgeon’s skills required for minimally invasive therapies are complicated since the surgeons have to manipulate various medical devices in a narrow surgical field with vision. Thus engineering assistance is important to realize safe and effective minimally invasive therapy. As the second vision of surgeon, we can utilize three dimensional medical imaging systems such as X-ray CT, MRI, Ultrasound Imaging, and high quality endoscope. Three dimensional anatomical information and function functional information registered to three dimensional position of the patient can be used to navigate surgeon’s therapy with assistance of information processing by high performance computers. As the second hand of a surgeon, robotic/mechatronic devices can be used to position various therapeutic/diagnostic devices in living body even when it is difficult for surgeons to manipulate it manually. Surgeons can overcome limitation of manual procedures by introduction of robotic devices. Robotics devices can provide more precise positioning, remote-controlled manipulation of medical devices in small and deep space of patient body where surgeons’ hands cannot approach. (3) Lab Tour: July 11 (Thu) 12:10-13:40 (4) Nano Bioelectronics and Biophotonics July 12 (Fri) 8:30-10:15 (Prof. Hitoshi TABATA)　 Outline: “Bioelectronics and Biophotonics: -Analysis・Diagnosis Technique of Bio Related Molecules by electronics and photonics-” 1. Overview of UV, Vis, IR spectroscopy -Wave length dispersion and dielectric response -Light(Photo) absorption -Light(Photo) excitation -Electron transfer -Relaxation 2. Bio & Medical Analysis and Diagnostic -Observing techniques（TR,ATR,Micro） -Spectral analysis -Data analysis 3. Vibration spectroscopy of bio related materials -Water -DNA -Amino acid, Protein -Cell 4. Advanced applications of Bio photonics　（Skin gas sensing for real time healthcare monitoring） (5) Nanotechnology and Materials Science for Nanoscale Cell Therapy July 12 (Fri) 10:25-12:10(Prof. Yuichi TEI) Outline: “Development of High-Performance Structural Biomaterials” Biomaterials play pivotal roles in tissue engineering and regenerative medicine; however, ideal structural biomaterials are still lacking due to poor mechanical strength and low biological functionality. This lecture will propose solutions to advance the performance of structural biomaterials via integrative innovations in three-dimensional fabrication technology, screening system for bioactive factors and design of structural unit. (6) Lab Tour: July 12 (Fri.) 12:10-13:40 <<Continue to Objectives>>

NOTE about Lab Tour: July 8 (Mon) 13:00-14:30: Please wear pants because you will need to wear dust-free garment over your clothes. (For female students, please do not wear a skirt.)

Evaluation 2 (two) credits will be given to those who have completed the following requirements within the deadline. The grade for the course will be given based on the 3 (three) essays (1 (one) essay from each sub-course) : 1. Attendance Students are required to attend more than 8 (eight) lectures out of 12 lectures during the period of the course. 2. Essays Students should submit one essay from each sub-course, Part I: Biotechnology, Part II: Biomedicine and Nanobiotechnology, and Part III: Nanophysics and Nanoelectronics. Students will be given four topics in each sub-course from which they should select one to write on. Submission deadline: 11:59 p.m., July 31 (Wed), 2019 (Japan Standard Time) Submit to: Prof. Satoshi Iwamoto (iwamoto@iis.u-tokyo.ac.jp)

基礎を固める（工学部共通）