Radiation Biology

【Basic Part】 1. Physics and chemistry of radiation absorption 放射線吸収の物理と化学 2. Molecular mechanism of DNA and chromosome damage and repair DNA・染色体損傷と修復の分子機構 3. Cell survival curves 細胞生存曲線 4. Radiosensitivity and cell age in the mitotic cycle 有糸分裂周期における放射線感受性と老化 5. Fractionated radiation and the dose rate effect 分割照射と線量率効果 6. Oxygen effect and reoxygenation 酸素効果と再酸素化 7. Linear energy transfer and relative biologic effectiveness線エネルギー付与と相対的生物効果 8. Acute radiation syndrome急性放射線症候群 9. Radioprotectors 放射線防護剤 10. Radiation carcinogenesis 放射線発がん 11. Heritable effects of radiation 放射線の遺伝的影響 12. Effects of radiation on the embryo and fetus 放射線の胎児影響 13. Radiation cataractogenesis 放射線白内障 14. Radiologic terrorism 放射線テロリズム 15. Molecular imaging 分子イメージング 16. Doses and risks in diagnostic radiology, interventional radiology and cardiology, and nuclear medicine 放射線診断、IVR、核医学における線量とリスク 17. Radiation protection 放射線防護 【Advanced Part】 1. Radiation dosimetry 放射線線量測定 2. Health physics 保健物理 3. Radiation therapy 放射線治療 4. Low dose radiation effects 低線量影響 Clinical Radiation Biology 1. Molecular biology of cancer がんの分子生物学 2. DNA damage response DNA損傷応答 3. DNA repair DNA修復 【Schedule】 April 15. (1) Mitsuru Uesaka (Graduate School of Engineering) Introduction I https://zoom.us/***** April 15. (2) Mitsuru Uesaka (Graduate School of Engineering) Introduction II Radiation physics and chemistry of radiation interaction Radiation sources https://zoom.us/***** April 22. (1) Noriko Hosoya (Laboratory of Molecular Radiology, CDBIM) Molecular biology of cancer https://zoom.us/***** April 22. (2) Teruaki Konishi (National Institute for Radiological Science) Molecular mechanism of DNA and chromosome damage and repair Cell survival curves Oxygen effect and reoxygenation Linear energy transfer and relative biologic effectiveness https://zoom.us/***** May 7. (1) Kiyoshi Miyagawa (Laboratory of Molecular Radiology, CDBIM) Early effects of radiation https://zoom.us/***** May 7. (2) Kiyoshi Miyagawa (Laboratory of Molecular Radiology, CDBIM) Late effects of radiation https://zoom.us/***** May 13. (1) Shinichi Yamashita (Graduate School of Engineering) Radiation Chemical Effect in Human Body Primary Processes of Radiation Damage to DNA https://zoom.us/***** May 13. (2) Shinichi Yamashita (Graduate School of Engineering) LET Effect and Track Structure Radiation Protection by Antioxidants https://zoom.us/***** May 20. (1) Kenji Shimazoe (Graduate School of Engineering) Radiation measurement and dosimetry Biological imaging https://zoom.us/***** May 20. (2) Kanabu Nawa (University of Tokyo Hospital) Radiation therapy https://zoom.us/***** May 27. (1) Hiroyuki Takahashi (Graduate School of Engineering) Health physics International activities https://zoom.us/***** May 27. (2) Hironobu Yanagie (Niigata University of Pharmacy and Applied Life Sciences) Principle and practice of neutron capture therapy https://zoom.us/*****

Reports (Three of at least 3 pages, at least 9 pages in tolal, out of all assigned) and attendance

”Radiobiology for the Radiologist”, Eric J Hall and Amato J.Giaccia, Wolters Kluwer, Lippincott Williams & Wilkins

基礎を固める（分野別基礎）

前提となる知識と項目：Basic Radiation Physics&Chemistry Basic Biology 応用先_分野と項目：Radiation Therapy Medical Physics Health Physics Nuclear Safety 平行履修：Applied Radiation Engineering,Introduction to Nuclear Engineering,Overview of Bioimaging 1,Quantum Beam Engineering,Radiation Safety